Daniel Tarullo, who had served at the Fed since 2009 and helped shape its response to the 2008-2009 financial crisis, said in a letter to Trump on Friday he would leave the central bank "on or around April 5."
While Democrats will probably raise questions about Clayton's ties to Wall Street at his confirmation hearing, they will not be able to block him without some support from Republicans.
Sen. Elizabeth Warren sent a letter to 33 wealth management firms, asking if they planned to reverse changes they have made to be compliant if there was a delay.